Particulates detection method

ABSTRACT

A particulate determination method determines by onetime scanning, the size of a particulate included in a plurality of particulates of various sizes which are arranged on a disc. False recognition of the number of particulates is avoided even when a plurality of particulates are adjacent to each other. A photodector detection signal is judged using plural threshold values according to the sizes of particulates to be detected. Results of determinations corresponding to the respective threshold values are stored on mutually independent memory maps. When counting particulates, a particulate size and a particulate count value are determined from a combination of stored data appearing in a scanning window at the same position on the respective memory maps.

This is a divisional application of U.S. patent application Ser. No.10/959,086, filed Oct. 7, 2004 now U.S. Pat. No. 7,430,480.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to a particulate determination method forcorrectly determining particulates when counting particulates havingsizes within a predetermined range, for each size, among particulates ofvarious sizes, or determining a specific particulate in a specimen thatis injected onto an analysis disc, thereby accurately determining thesizes and numbers of the respective particulates.

2. Description of the Related Art

A conventional particulate determination method will be described withreference to FIG. 19( a).

FIG. 19( a) shows a particulate 51 as a target of measurement, tracks52, and a laser beam 53.

In a conventional analysis device which injects a specimen onto ananalysis disc and counts the number of specific particulates existing inthe specimen, tracks 52 are spirally carved on the disc like an opticaldisc such as a CD-ROM, and the laser beam 53 is controlled so as to moveon the tracks 52 along the tracks 52 during disc rotation.

On the other hand, the particulate 51 as a target of measurement islarger than the width of the track 52, and it lies over several tracks52. When the laser moves across the tracks 52, a signal change occurs ina laser beam receptor (Photo Detector, hereinafter referred to as PD)which receives the laser beam 53 that has passed through the disc andperforms light-to-electricity conversion, depending on whether theparticulate 51 exists on the tracks 52 or not.

When it is judged that a particulate 51 is on the tracks 52 byprocessing the signal change, “1” is stored in a memory. Otherwise, “0”is stored in the memory. From a data array thus obtained, the length of1s in the direction of the radius of the disc is detected, thereby todetermine the size of the particulate and count the number of theparticulates.

As a method for determining the sizes of particulates and counting thenumber of particulates, there is proposed a method of, using a rectanglescanning window, performing detection while changing the size of thescanning window for each size of a desired particulate (for example,Japanese Published Patent Application No. 2000-287077).

FIG. 19( b) is a diagram for explaining a particulate size determinationand counting method using a scanning window.

For example, when detecting a particulate having a size equivalent to 6tracks from among particulates having sizes equivalent to 1˜11 tracks,initially scanning is carried out using a window having a size of 6×X1while shifting the window one by one in an X direction, and positions inwhich all rows in the window include “1” are counted.

Next, scanning is carried out using a window having a size of 7×X1 whileshifting the window one by one in the X direction, and positions inwhich all rows include “1” are counted.

Thereby, the number of particulates each lying over six or more tracksand the number of particulates each lying over seven or more tracks areobtained, and the number of particulates each having a size equivalentto six tracks can be obtained from a difference between the numbers.

The X1 is an integer value larger than a position deviation range of “1”due to uneven disc rotation or variations in signal detection.Therefore, even when a position error of “1” occurs in each track, itcan be detected as “1” from the same particulate.

Further, FIG. 20( a) is a diagram illustrating particulate detection byanother particulate determination method.

An analysis disc has a light reflectivity and permeability, andcomprises a base disc in which tracks 201 for guiding or data recordingare spirally carved. The analysis disc also has an upper cover having aninjection port, and an adhesive layer for bonding the upper cover to thebase disc, and forming a flow path.

The outline of the analysis disc is identical to those of optical discssuch as CD-ROM and CD-RW except its thickness. When the analysis disc isconveyed into an analysis device, it is chucked with a motor having aturn table, whereby the analysis disc can rotate about the center of thedisc diameter.

A specimen for examination is injected into the analysis disc, andpasses through the flow path constituted by the adhesive layer, thelower surface of the upper cover, and the upper surface of the basedisc, and is subjected to pretreatment such as centrifugal separationutilizing a centrifugal force that is generated by the rotation of theanalysis disc. Thus, particulates as measurement target components inthe specimen reach an area where measurement should be carried out.

In the measurement area, the particulates in the specimen exist on thesurface of the base disc due to an adsorption factor (antibody) thatadsorbs specific particulates applied onto the surface of the base disc,and each particulate has a size larger than the width of the track 201and lies over plural tracks 201 as shown in FIG. 20( a). Therefore, thepresence or absence of a particulate on the tracks 201 can be determinedby making the laser beam 202 follow the tracks 201 and detect adifference signal of passing light.

To be specific, the analysis device has a two-part split PD forreceiving the laser beam 202 that has passed through the analysis disc.The analysis device is located so that a spot of the laser outputtedfrom the optical pickup is positioned in the center of the PD when thereis no particulate on the analysis disc.

When a particulate crosses the laser, the position of the laser spotwhich is positioned in the center of the two-part split PD is changeddue to a change in refraction of the beam.

By obtaining a difference between the signals from the two-part splitPD, the position change of the laser spot is detected as an S-shapedpattern (hereinafter referred to as an S-shaped curve) having a maximumvalue and a minimum value according to the size of the measurementtarget. Consequently, the presence or absence of a particulate on thetracks can be determined by presence/absence of the S-shaped curve.

The difference signal from the two-part split PD is stored in a memoryat regular intervals. When the S-shaped curve is detected, it is judgedthat a particulate 203 exists, and “1” is stored in the memory.Otherwise, “0” is stored in the memory.

During the analysis, the number of particulates should be counted foreach size. A size determination and counting are carried out as follows.Using rectangle windows, the memory is scanned while changing the windowfor each size of particulate to be obtained. The presence or absence ofa particulate of the desired size is determined according topresence/absence of a particulate that matches the condition of thewindow (for example, Japanese Published Patent Application No.2000-287077).

FIG. 20( b) is a diagram for explaining a particulate determinationmethod using a conventional operation window 204 for particulate sizedetermination.

For example, when detecting a particulate having a size equivalent to 6tracks from among particulates having various sizes equivalent to 1-11tracks, initially scanning is carried out using a window having a sizeof 6×X1 while shifting the window one by one in the X direction as thetrack direction to detect a position where all rows include “1”.

When the window is shifted by one in the X direction to performdetection of a next position after “1” has been detected in every row inthe window, the just detected “1” might be read again.

So, once-read “1” is deleted from the memory to prevent one particulatefrom being counted twice.

After the scanning using the 6×X1 window is ended, another scan iscarried out using a window having a size of 7×X1 while shifting thewindow one by one in the X direction. Since “1” has been deleted fromthe memory in the previous scanning, detection of S-shaped curves iscarried out again, and the detected S-shaped curves are stored in thememory.

Then, scanning is carried out in like manner as that for the scanningwith the 6×X1 window, and positions where all rows in the window include“1” are counted.

Thereby, the number of particulates each lying over six or more tracksand the number of particulates each lying over seven or more tracks areobtained, and the number of particulates each having a size equivalentto six tracks can be obtained from a difference between the numbers. TheX1 is an integer value larger than a position deviation range of “1” dueto uneven disc rotation or variations in signal detection. Therefore,even when a position error of “1” occurs in each track, it can bedetected as “1” from the same particulate.

The conventional particulate determination method is carried out asdescribed above. When particulates are adjacent to each other in thedirection of the radius of the disc, 1s are continuously stored on thememory in a section corresponding to the adjacent particulates.Therefore, when scanning the memory using a scanning window, since 1scontinue, a boundary of the adjacent particulates cannot be accuratelydetected. As a result, a problem occurs because several particulatesadjacent to each other are undesirably detected as one particulate.

Further, in the above-mentioned conventional method, it is necessary toperform a plurality of scans while changing the size of the scanningwindow to determine the size of particulate. Further, since only onememory array is used, storage steps into the memory as many as thenumber of scannings are required, and therefore, a plurality of scansare required. As a result, particulate size determination and countingtake much time.

Furthermore, in the conventional particulate determination method, whena plurality of particulates are adjacent to each other on the analysisdisc, a number of S-shaped curves equal to the number of theparticulates are detected in the track direction. However, in the radiusdirection, an end of a particulate abuts a beginning of anotherparticulate. Therefore, after an end of a particulate is detected on atrack, a beginning of another particulate is detected on a next track,and thereby 1s continue in the radius direction on the memory.

In this case, when the memory is scanned using a detection window, onlya large particulate is detected although there are actually a pluralityof particulates, and therefore, accurate counting cannot be carried out.

The present invention is made to solve the above-described problems andhas for its object to provide a high-speed and high-precisionparticulate determination method which can determine the size ofparticulate by onetime scanning and, even when there are adjacentparticulates, can correctly detect that these particulates areindividual particulates.

Further, it is another object of the present invention to provide aparticulate determination method which can accurately determine the sizeof particulate even when a plurality of particulates are adjacent toeach other in the radius direction on the tracks.

BRIEF SUMMARY OF THE INVENTION

According to one embodiment of the invention, there is provided aparticulate determination method for determining independence of aparticulate as a measurement target according to a specific signalpattern that appears when a memory expressing a distribution of anelectric signal is scanned along a predetermined scanning direction. Themethod includes: a data storage step of storing a plurality of differentrecognition conditions based on signal levels of the specific signalpattern, flags that are obtained when results of determinationsaccording to the respective recognition conditions are true, and flagsthat are obtained when the results of determinations are false, into aplurality of memories which are provided correspondingly to therespective recognition conditions; and a particulate determination stepof scanning arrays of the flags that are stored in the plural memoriesusing scanning windows having the same predetermined size, and comparingrows of the flags in the same region on the memory expressing thedistribution of the electric signal, among the arrays of the flagsstored in the plural memories, thereby determining independence of theparticulate. Independence of a particulate which is described in thisspecification indicates that, when a plurality of particulates areadjacent each other, the state is an assemblage of individualparticulates. By detecting or determining independence of eachparticulate, the number of particulates can be counted when a pluralityof particulates are adjacent to each other.

According to a second embodiment of the invention, the specific signalpattern is an S-shaped pattern (hereinafter referred to as an S-shapedcurve) having a maximum value and a minimum value according to the sizeof the measurement target. The several recognition conditions include acondition that the size of the S-shaped curve is larger than apredetermined first threshold value, and several conditions adoptingthreshold values that are successively larger than the first thresholdvalue.

According to a third embodiment of the invention, during the particulatedetermination step, it is determined as to whether the flags, which areobtained when the results of determinations in a plurality of scanningwindows are true, exist continuously over a predetermined number of rowsor more on the respective arrays of the flags. The independence of theparticulate is determined by a combination of the results ofdeterminations with the respective windows.

According to a fourth embodiment of the invention, there is provided aparticulate determination method for determining independence of aparticulate as a measurement target according to a specific signalpattern that appears when a memory expressing a distribution of anelectric signal is scanned along a predetermined scanning direction. Themethod includes a data storage step of storing two different recognitionconditions based on signal levels of the specific signal pattern. Morespecifically, flags that are obtained when results of determinationsaccording to the respective recognition conditions are true and flagsthat are obtained when the results of determinations are false arestored into two memories which are provided corresponding to therespective recognition conditions. The method also includes aparticulate determination step of scanning arrays of the flags that arestored in the two memories using two scanning windows having the samepredetermined size, and comparing rows of the flags in the same regionon the memory expressing the distribution of the electric signal, on thearrays of the flags stored in the two memories, thereby determiningindependence of the particulate.

According to a fifth embodiment of the invention, the specific signalpattern is an S-shaped curve having a maximum value and a minimum valueaccording to the size of the measurement target. The two recognitionconditions include a condition that the size of the S-shaped curve islarger than a predetermined first threshold value, and a condition thatthe size of the S-shaped curve is larger than a predetermined secondthreshold value that is larger than the first threshold value.

According to a sixth embodiment of the invention, during the particulatedetermination step, it is determined as to whether the flags, which areobtained when the results of determinations in the two scanning windowsare true, exist continuously over a predetermined number of rows or moreon the respective arrays of the flags. When a combination of the resultsof determinations using the respective scanning widows indicates thatthe result of determination using the first threshold value is truewhile the result of determination using the second threshold value istrue, an individual particulate is recognized. When the combinationindicates that the result of determination using the first thresholdvalue is true while the result of determination using the secondthreshold value is false, a plurality of particulates is recognized. Thenumber of the particulates being calculated from the number rows inwhich the flags, which are obtained when the results of determinationswithin the scanning windows are true, continuously exist.

According to a seventh embodiment of the invention there is provided aparticulate determination method for determining independence of aparticulate as a measurement target according to a specific signalpattern that appears when a memory expressing a distribution of anelectric signal is scanned along a predetermined scanning direction. Themethod includes a data storage step of storing a predeterminedrecognition condition based on the shape of the specific signal pattern.More, specifically, a flag that is obtained when a result ofdetermination according to the recognition condition is true, and a flagthat is obtained when the result of determination is false, are storedinto a memory. A particulate determination step includes scanning anarray of the flags stored in the memory using a scanning window having apredetermined size, and determining independence of the particulate fromrows of the flags obtained when the result of determination in thescanning window is true.

According to an eighth embodiment of the invention, the shape of thespecific signal pattern is an S-shaped curve having a maximum value anda minimum value according to the size of the measurement target. The andthe predetermined recognition condition is that a distance from a changestart position to a change end position of the S-shaped curve in thetrack direction is larger than a predetermined value.

According to a ninth embodiment of the invention, the shape of thespecific signal pattern is an S-shaped curve having a maximum value anda minimum value according to the size of the measurement target. Thepredetermined recognition condition is that a distance from a changestart position to a change end position of the S-shaped curve in thetrack direction is larger than a predetermined value, and adjacentS-shaped curves have different lengths from a change start position to achange end position in the track direction.

According to a tenth embodiment of the invention, the particulatedetermination method includes a step of generating the signal pattern byirradiating an analysis medium into which the measurement target isinjected, with a laser beam, and optically reading the analysis medium.The method also includes a step of providing a reference target having apredetermined size corresponding to the size of the measurement targetin a predetermined region of the analysis medium, and setting a signalpattern obtained by reading the reference target before measurement, asa reference pattern. Moreover, the method includes a step of performingmeasurement on the basis of a result of comparison with the referencepattern, in the data storage step.

According to an eleventh embodiment of the invention the specific signalpattern and the reference pattern are S-shaped curves each having amaximum value and a minimum value according to the size of themeasurement target. Measurement is carried out only when the result of acomparison with the reference pattern is that either the maximum valueor the minimum value of the measurement target exists within thedistribution range of the reference pattern.

According to a twelfth embodiment of the invention, the specific signalpattern and the reference pattern are S-shaped curves each having amaximum value and a minimum value according to the size of themeasurement target. Measurement is carried out only when the result ofcomparison with the reference pattern is that both of the maximum valueand the minimum value of the measurement target exist within thedistribution range of the reference pattern.

According to a thirteenth embodiment of the invention, the particulatedetermination method is realized by a particulate determination devicecomprising an optical pickup which is provided movably with respect tothe analysis disc, and comprises an optical system including a lightsource, an objective lens and the like. The particulate determinationdevice also includes an actuator for driving the objective lens in arotation axis direction and a radius direction of the analysis disc, anda photodetector for converting reflected light from the analysis discinto electricity. Moreover, the device includes: a spindle motor as arotation driving means for the analysis disc; a servo control circuitfor performing focus servo control, tracking servo control, and spindleservo control on the basis of a signal outputted from the opticalpickup; a laser light reception unit (Photo Detector, hereinafterreferred to as PD) for receiving a laser light which has been emittedfrom the optical pickup and has passed through the analysis disc, andconverting the light into electricity; an S-shaped curve detectioncircuit for detecting an S-shaped curve on the basis of an electricsignal outputted from the PD; a memory for holding the output of theS-shaped curve detection circuit; and a particulate recognition circuitfor recognizing a particulate on the basis of data stored in the memory.

According to a fourteenth embodiment of the invention, there is provideda method for determining independence of a particulate as a measurementtarget which is injected into an analysis disc. The method includes: astep of storing, into a memory, an array of binary data comprising 0sand 1s, which is determined on the basis of the presence or absence ofthe particulate and the size of the particulate; and a step ofdetermining the size of the particulate on the basis of the data arrayin a track direction and a radius direction of the analysis disc.

According to a fifteenth embodiment of the invention the data array inthe track direction has a large number of 1s when an S-shaped curve,which is a particulate detection signal and has a maximum value and aminimum value, is large, and has a small number of 1s when the S-shapedcurve is small.

According to a sixteenth embodiment of the invention, particulate, it isdetermined that there are a plurality of particulates when it isdetected that 1s continue in the data array in the radius direction, andthe number of 1s in the data array in the track direction decreases atsome row.

According to a seventeenth embodiment of the invention, there isprovided a method for determining independence of a particulate as ameasurement target which is injected into an analysis disc. The methodincludes a step of writing a data array based on the size of an S-shapedcurve which is a particulate detection signal and has a maximum valueand a minimum value, on a memory, in a position next to a data arrayindicating the presence or absence of a particulate. It should beunderstood that, in this embodiment,

According to continuous 1s do not exist in the encoded data array.

According to a nineteenth embodiment of the invention, there is provideda method for determining independence of a particulate as a measurementtarget which is injected into an analysis disc. When an S-shaped curveof a data array that is obtained when a particulate is detected issmaller than an S-shaped curve of a data array in a previous row, dataare not stored on a memory. It should be understood that the data arraycomprises data indicating the presence or absence of a particulate, anddata indicating the size of a particulate.

According to a twenty-first embodiment of the invention, the particulatedetermination method includes a step of writing “0” on the memory in aposition next to “11” that is a data array indicating the presence orabsence of a particulate. Also included is a step of writing, on thememory, a data array in which continuous 1s do not exist, which isdetermined on the basis of the size of an S-shaped curve that is aparticulate detection signal and has a maximum value and a minimumvalue.

According to a twenty-second embodiment of the invention, theparticulate determination method determines that there are a pluralityof particulates when 1s continue in the data array in the radialdirection, and the number of 1s in the data array in the track directionis the same in each row.

According to a twenty-third embodiment of the invention, the particulatedetermination method is realized by a particulate determination devicecomprising an optical pickup which is provided movably with respect tothe analysis disc, and comprises an optical system including a lightsource, an objective lens and the like, an actuator for driving theobjective lens in a rotation axis direction and a radius direction ofthe analysis disc, and a photodetector for converting a reflected lightfrom the analysis disc into electricity. The particulate determinationdevice also includes: electricity; a spindle motor as a rotation drivingmeans for the analysis disc; a servo control circuit for performingfocus servo control, tracking servo control, and spindle servo controlon the basis of a signal outputted from the optical pickup; a PD forreceiving a laser light which has been emitted from the optical pickupand has passed through the analysis disc, and converting the light intoelectricity; an S-shaped curve detection circuit for detecting anS-shaped curve on the basis of an electric signal outputted from the PD;a memory for holding an array of binary data which is processed on thebasis of an output signal from the S-shaped curve detection circuit; anda particulate recognition circuit for recognizing a particulate on thebasis of data stored in the memory.

EFFECTS OF THE INVENTION

According to one aspect of the present invention, there is provided aparticulate determination method for determining independence of aparticulate as a measurement target according to a specific signalpattern that appears when a memory expressing a distribution of anelectric signal is scanned along a predetermined scanning direction, andthe method includes: a data storage step of storing a plurality ofdifferent recognition conditions based on signal levels of the specificsignal pattern, flags that are obtained when results of determinationsaccording to the respective recognition conditions are true, and flagsthat are obtained when the results of determinations are false, intoplural memories which are provided correspondingly to the respectiverecognition conditions; and a particulate determination step of scanningarrays of the flags that are stored in the plural memories usingscanning windows having the same predetermined size, and comparing rowsof the flags in the same region on the memory expressing thedistribution of the electric signal, among the arrays of the flagsstored in the plural memories, thereby determining independence of theparticulate. Therefore, the number of particulates which are continuousin the direction of the radius of the disc can be counted withoutincorrectly recognizing the particulates, by comparing the states of theflags among the plural memory maps.

According to the present invention, in the particulate determinationmethod, the specific signal pattern is an S-shaped pattern (hereinafterreferred to as an S-shaped curve) having a maximum value and a minimumvalue according to the size of the measurement target; and the pluralrecognition conditions include a condition that the size of the S-shapedcurve is larger than a predetermined first threshold value, and pluralconditions adopting threshold values that are successively larger thanthe first threshold value. Therefore, the number of particulates whichare continuous in the direction of the radius of the disc can be countedwithout wrongly recognizing the particulates, by setting appropriatethreshold values.

According to the present invention, in the particulate determinationmethod, in the particulate determination step, it is determined as towhether the flags, which are obtained when the results of determinationsin the plural scanning windows are true, exist continuously over apredetermined number of rows or more on the respective arrays of theflags, and independence of the particulate is determined by acombination of the results of determinations with the respectivewindows. Therefore, the number of particulates which are continuous inthe direction of the radius of a disc can be counted without wronglyrecognizing the particulates, according to the results of determinationsusing the scanning windows.

According to another aspect of the present invention, there is provideda particulate determination method for determining independence of aparticulate as a measurement target according to a specific signalpattern that appears when a memory expressing a distribution of anelectric signal is scanned along a predetermined scanning direction, andthe method includes: a data storage step of storing two differentrecognition conditions based on signal levels of the specific signalpattern, flags that are obtained when results of determinationsaccording to the respective recognition conditions are true, and flagsthat are obtained when the results of determinations are false, into twomemories which are provided correspondingly to the respectiverecognition conditions; and a particulate determination step of scanningarrays of the flags that are stored in the two memories using twoscanning windows having the same predetermined size, and comparing rowsof the flags in the same region on the memory expressing thedistribution of the electric signal, on the arrays of the flags storedin the two memories, thereby determining independence of theparticulate. Therefore, the number of particulates which are continuousin the direction of the radius of a disc can be counted without wronglyrecognizing the particulates, by comparing the states of the flagsbetween the two memory maps corresponding to the threshold values ofdifferent levels.

According to the present invention, in the particulate determinationmethod, the specific signal pattern is an S-shaped curve having amaximum value and a minimum value according to the size of themeasurement target; and the two recognition conditions include acondition that the size of the S-shaped curve is larger than apredetermined first threshold value, and a condition that the size ofthe S-shaped curve is larger than a predetermined second threshold valuethat is larger than the first threshold value. Therefore, the number ofparticulates which are continuous in the direction of the radius of adisc can be counted without wrongly recognizing the particulates, bysetting appropriate threshold values.

According to the present invention, in the particulate determinationmethod, in the particulate determination step, it is determined as towhether the flags, which are obtained when the results of determinationsin the two scanning windows are true, exist continuously over apredetermined number of rows or more on the respective arrays of theflags; when a combination of the results of determinations using therespective scanning widows indicates that the result of determinationusing the first threshold value is true while the result ofdetermination using the second threshold value is true, an individualparticulate is recognized; and when the combination indicates that theresult of determination using the first threshold value is true whilethe result of determination using the second threshold value is false,plural particulates are recognized, the number of the particulates beingcalculated from the number rows in which the flags, which are obtainedwhen the results of determinations within the scanning windows are true,continuously exist. Therefore, the number of particulates which arecontinuous in the direction of the radius of a disc can be countedwithout wrongly recognizing the particulates, according to the resultsof determinations using the scanning windows.

According to another aspect of the present invention, there is provideda particulate determination method for determining independence of aparticulate as a measurement target according to a specific signalpattern that appears when a memory expressing a distribution of anelectric signal is scanned along a predetermined scanning direction, andthe method includes: a data storage step of storing a predeterminedrecognition condition based on the shape of the specific signal pattern,a flag that is obtained when a result of determination according to therecognition condition is true, and a flag that is obtained when theresult of determination is false, into a memory; and a particulatedetermination step of scanning an array of the flags stored in thememory using a scanning window having a predetermined size, anddetermining independence of the particulate from rows of the flagsobtained when the result of determination in the scanning window istrue. Since the particulate recognition condition corresponding to thesize of a particulate to be detected has previously been set, even whenplural particulates adjoin to each other in a direction perpendicular tothe scanning direction, the target particulate is not misidentified,whereby the number of particulates which are continuous in the directionof the radius of a disc can be counted without wrongly recognizing theparticulates.

According to the present invention, in the particulate determinationmethod, the shape of the specific signal pattern is an S-shaped curvehaving a maximum value and a minimum value according to the size of themeasurement target; and the predetermined recognition condition is thata distance from a change start position to a change end position of theS-shaped curve in the track direction is larger than a predeterminedvalue. Therefore, the number of particulates which are continuous in thedirection of the radius of a disc can be counted without wronglyrecognizing the particulates, by setting appropriate threshold values.

According to the present invention, in the particulate determinationmethod, the shape of the specific signal pattern is an S-shaped curvehaving a maximum value and a minimum value according to the size of themeasurement target; and the predetermined recognition condition is thata distance from a change start position to a change end position of theS-shaped curve in the track direction is larger than a predeterminedvalue, and adjacent S-shaped curves have different lengths from a changestart position to a change end position in the track direction.Therefore, the number of particulates which are continuous in thedirection of the radius of a disc can be counted without wronglyrecognizing the particulates, by setting appropriate threshold values.

According to the present invention, the particulate determination methodincludes: a step of generating the signal pattern by irradiating ananalysis medium into which the measurement target is injected, with alaser beam, and optically reading the analysis medium; a step ofproviding a reference target having a predetermined size correspondingto the size of the measurement target in a predetermined region of theanalysis medium, and setting a signal pattern obtained by reading thereference target before measurement, as a reference pattern; and a stepof performing measurement on the basis of a result of comparison withthe reference pattern, in the data storage step. Therefore, only theparticulates having the size equal to the size of the measurement targetcan be counted by comparing the reference value of the detection signalbefore it is inputted, with the detection signal obtained when theactual particulate recognition is carried out. Even when pluralparticulates adjoin to each other in a direction perpendicular to thescanning direction, the target particulate is not misidentified, wherebythe number of particulates which are continuous in the direction of theradius of a disc can be counted without wrongly recognizing theparticulates.

According to the present invention, in the particulate determinationmethod, the specific signal pattern and the reference pattern areS-shaped curves each having a maximum value and a minimum valueaccording to the size of the measurement target; and measurement iscarried out only when the result of comparison with the referencepattern is that either the maximum value or the minimum value of themeasurement target exists within the distribution range of the referencepattern. Therefore, the number of particulates which are continuous inthe direction of the radius of a disc can be counted without wronglyrecognizing the particulates, by setting appropriate threshold values.

According to the present invention, in the particulate determinationmethod, the specific signal pattern and the reference pattern areS-shaped curves each having a maximum value and a minimum valueaccording to the size of the measurement target; and measurement iscarried out only when the result of comparison with the referencepattern is that both of the maximum value and the minimum value of themeasurement target exist within the distribution range of the referencepattern. Therefore, the number of particulates which are continuous inthe direction of the radius of a disc can be counted without wronglyrecognizing the particulates, by setting appropriate threshold values.

According to another aspect of the present invention, there is provideda method for determining independence of a particulate as a measurementtarget which is injected into an analysis disc, and the method includes:a step of storing, into a memory, an array of binary data comprising 0sand 1s, which is determined on the basis of presence/absence of theparticulate and the size of the particulate; and a step of determiningthe size of the particulate on the basis of the data array in a trackdirection and a radius direction of the analysis disc. Therefore, evenwhen plural particulates adjoin each other in the radius direction onthe tracks, the sizes of the particulates can be accurately determinedto count the particulates.

According to another aspect of the present invention, there is provideda method for determining independence of a particulate as a measurementtarget which is injected into an analysis disc, and this methodincludes: a step of writing “0” on the memory in a position next to “11”that is a data array indicating presence/absence of a particulate; and astep of writing, on the memory, a data array in which continuous 1s donot exist, which is determined on the basis of the size of an S-shapedcurve that is a particulate detection signal and has a maximum value anda minimum value. Therefore, in the step of detecting presence/absence ofparticulate, only the arrays of “11” should be detected, without thenecessity of observing the number of 1s in the respective rows in thewindow. Therefore, detection of particulates can be carried out withoutcomplicated operation of the detection window. Further, in the step ofdetermining the particulate size, even when plural particulates on thetracks adjoin to each other in the radius direction, the size of eachparticulate can be accurately determined to count the particulates.Furthermore, when the data array indicating the size of the S-shapedcurve is composed of five or more digits, the number of handleable dataincreases, whereby finer division is possible, and it is advantageouswhen fine division is required.

According to another aspect of the present invention, there is provideda method for determining independence of a particulate as a measurementtarget which is injected into an analysis disc, wherein, when anS-shaped curve of a data array that is obtained when a particulate isdetected is smaller than an S-shaped curve of a data array in a previousrow, data are not stored on a memory. Therefore, even when pluralparticulates on the tracks adjoin to each other in the radius direction,the size of each particulate can be accurately determined to count theparticulates.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram illustrating an analysis device using aparticulate determination method according to a first embodiment of thepresent invention.

FIG. 2( a) is a diagram illustrating examples of particulates andS-shaped curves obtained in accordance with the first embodiment of theinvention.

FIG. 2( b) is a diagram illustrating examples of particulates andS-shaped curves obtained in accordance with the first embodiment of theinvention.

FIG. 3 is a diagram illustrating a table expressing the relationshipbetween the types of the particulates and threshold values.

FIG. 4 is a diagram illustrating examples of particulates which arearranged in the radial direction a disc according to the first andsecond embodiments.

FIG. 5( a) is a diagram of an example of a memory array according to thefirst and second embodiments.

FIG. 5( b) is a diagram of an example of a memory array according to thefirst and second embodiments.

FIG. 5( c) is a diagram of an example of a memory array according to thefirst and second embodiments.

FIG. 5( d) is a diagram of an example of a memory array according to thefirst and second embodiments.

FIG. 6( a) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the firstembodiment.

FIG. 6( b) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the firstembodiment.

FIG. 6( c) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the firstembodiment.

FIG. 6( d) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the firstembodiment.

FIG. 7 is a flowchart illustrating a particulate recognition process inthe particulate determination method according to the first embodiment.

FIG. 8 is a flowchart illustrating a particulate size determinationprocess in the particulate determination method according to the firstembodiment.

FIG. 9 is a diagram of an example of a convex signal in the particulatedetermination method according to the first embodiment.

FIG. 10 is a diagram illustrating a table expressing the relationshipbetween the types of the particulates and threshold values according tothe second embodiment.

FIG. 11( a) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the secondembodiment.

FIG. 11( b) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the secondembodiment.

FIG. 11( c) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the secondembodiment.

FIG. 11( d) is a diagram illustrating the state of a scanning windowemployed in the particulate determination method according to the secondembodiment.

FIG. 12 is a flowchart illustrating a particulate recognition process inthe particulate determination method according to the second embodiment.

FIG. 13 is a diagram of an example of a convex signal in the particulatedetermination method according to the second embodiment.

FIG. 14( a) is a diagram illustrating arrangement of particulates on anoptical disc in a particulate determination method according to a thirdembodiment of the present invention.

FIG. 14( b) is a diagram illustrating examples of signal patterns whichare obtained from the arrangement of the particulates on the opticaldisc in the particulate determination method according to the thirdembodiment.

FIG. 15 is a diagram for explaining an example of a memory array in theparticulate determination method according to the third embodiment.

FIG. 16 is a diagram illustrating the relationship between a particulateand tracks in the particulate determination method according to thethird embodiment.

FIG. 17 is a diagram illustrating an example of a layout range of ameasurement target on an optical disc, and examples of layout ranges ofreference targets for obtaining reference patterns, in a particulatedetermination method according to a fourth embodiment of the presentinvention.

FIG. 18 is a diagram of examples of S-shaped curves which are obtainedfrom the reference targets and the measurement target, in theparticulate determination method according to the fourth embodiment.

FIG. 19( a) is a diagram illustrating the relationship between aparticulate and tracks in the particulate determination method accordingto the prior art.

FIG. 19( b) is a diagram of an example of a memory array in theparticulate determination method according to the prior art.

FIG. 20( a) is a diagram illustrating particulate detection in theconventional particulate determination method.

FIG. 20( b) is a diagram illustrating the conventional particulatedetermination method using a window.

FIG. 21( a) is a diagram illustrating particulate detection in aparticulate determination method according to a fifth embodiment of thepresent invention.

FIG. 21( b) is an enlarged view of an S-shaped curve signal in theparticulate determination method according to the fifth embodiment ofthe present invention.

FIG. 22( a) is a diagram illustrating the particulate determinationmethod according to the fifth embodiment of the present invention.

FIG. 22( b) is a graph expressing the number of 1s which are detected ina window in the particulate determination method according to the fifthembodiment of the present invention.

FIG. 23( a) is a diagram illustrating a particulate determination methodaccording to a sixth embodiment of the present invention.

FIG. 23( b) is a diagram illustrating a data array stored in a memory inthe particulate determination method according to the sixth embodiment.

FIG. 24( a) is a diagram illustrating a particulate determination methodaccording to a seventh embodiment of the present invention.

FIG. 23( b) is a diagram illustrating a data array stored in a memory inthe particulate determination method according to the seventhembodiment.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Hereinafter, embodiments of particulate determination methods accordingto the present invention will be described with reference to thedrawings.

Embodiment 1

FIG. 1 is a block diagram illustrating an analysis device employing aparticulate determination method according to a first embodiment of thepresent invention. Hereinafter, the fundamental operation of the devicewill be described.

When an analysis disc 1 on which particulates as an analysis target 8are placed is mounted on an analysis device, rotation control (CAVcontrol) for a spindle motor 4 is carried out by a servo control circuit3 connected to a microcomputer 2.

Next, the analysis disc 1 is irradiated with a laser beam 7 emitted froman optical pickup 5. The servo control circuit 3 performs focus servo,tracking servo, and traverse control to trace tracks formed of pits orgrooves on the basis of a reproduced output signal from the opticalpickup 5, and simultaneously, detects address information recorded onthe tracks of the analysis disc 1, and controls rotation of the spindlemotor 4 so as to make the linear velocity constant (CLV control).

Thus, tracing, which is an operation to make the optical pickup 5 followthe tracks on the disc 1, is carried out, and reflected light ortransmitted light from the analysis disc 1 at this time is detected by aPD (photodetector) 6 (FIG. 1 shows the case of transmitted light),whereby scanning for analyzing the analysis target 8 can be carried outon the basis of the detected signal.

Next, a description will be given of a method for detecting asingle-body particulate from the signal detected by the PD 6 duringparticulate recognition at scanning (hereinafter referred to as PDdetection signal), using an S-shaped curve detection circuit 9 and aparticulate recognition circuit 10, with reference to FIG. 2, whichmethod is a feature of the present invention.

FIG. 2( a) shows an example wherein the centers of three particulates 22having different sizes are positioned on the same track 21.

FIG. 2( b) shows a waveform of a PD detection signal which is obtainedwhen the track 21 is traced in the example of FIG. 2( a).

As shown in FIG. 2( b), the waveform is constant when no particulateexists, while it curves in an S shape when a particulate exists. In thisfirst embodiment, the amplitude of the S-shaped curve is proportional tothe size of the particulate.

The S-shaped curve detection circuit 9 detects the change in the PDdetection signal on the basis of a predetermined recognition condition,and writes “0” as a flag on the memory when no S-shaped curve isdetected, while writes “1” as a flag on the memory 11 when an S-shapedcurve is detected.

The predetermined recognition condition is as follows. For example,using the amplitude of the PD detection signal and a predeterminedthreshold value, it is determined that no S-shaped curve is detectedwhen the amplitude is smaller than the predetermined threshold value,while it is determined that an S-shaped curve is detected when theamplitude is larger than the threshold value.

As described above, the S-shaped curve detection circuit 9 reflects thepresence or absence of an S-shaped curve in the PD detection signal ontothe memory. The data in the memory 11 thus generated form atwo-dimensional memory array in which one direction indicates the trackdirection of the disc while the other direction indicates the radialdirection of the disc.

Further, in this first embodiment, a plurality of recognition conditionsare used for onetime scanning to constitute a plurality of memory arraysto which the results of determinations according to the respectiverecognition conditions are reflected.

In this first embodiment, it is assumed that there are three kinds ofparticulates A, B, and C having different sizes (A<B<C), and fourthreshold values a1, a2, a3, and a4 (a1<a2<a3<a4) are used as theabove-mentioned predetermined recognition conditions.

Hereinafter, a description will be given of a method for setting therecognition conditions according to the first embodiment, i.e., therespective threshold values.

As shown in FIG. 2( a), a track that passes through the centers of thethree particulates A, B, and C will be considered. FIG. 2( b) is a graphillustrating the relationship between the S-shaped curves of theparticulates A, B, and C that are generated on the track, and the fourthreshold values a1, a2, a3, and a4.

As shown in FIG. 2( b), the threshold values a1˜a4 are set so that theS-shaped curves detected at the respective threshold values havedifferent sizes.

Hereinafter, memory arrays A1˜A4 which are constituted corresponding tothe respective threshold values will be described in detail. FIG. 3shows a table expressing the relationship between the different types ofparticulates and the threshold values according to the first embodiment.In FIG. 3, each numerical value indicates the number of rows whichinclude 1s that appear continuously in the radial direction on thememory array, when the respective particulates A, B, and C havingdifferent sizes exist.

For example, as for the particulate C, 1s appear continuously over fiverows in the memory array A1 corresponding to the threshold value a1,over three rows in the memory array A2 corresponding to the thresholdvalue a2, and in only one row in the memory array A3 corresponding tothe threshold value a3. No 1 appears in the memory array A4corresponding to the largest threshold value a4. In this way, the numberof 1s that appear on the memory array decreases with an increase in thethreshold value.

When the particulates shown in FIG. 3 are observed according to thetypes, the level of the threshold value at which no 1 appears becomeslarger according to the size of the particulate. For example, as for thesmallest particulate A, the frequency of 1 becomes zero with respect tothe threshold values equal to or larger than the threshold value a2.However, as for the largest particulate C, the frequency of 1 becomeszero with respect to the threshold value a4 alone.

The table shown in FIG. 3 is used for determining the size ofparticulate, which will be described later. Accordingly, this tableshould be prepared in advance, and it is necessary to uniquely determinethe type of particulate from the smallest threshold value at which no 1appears, using this table. As for the respective threshold values,appropriate values are set so as to uniquely determine all types ofparticulates.

The memory arrays A1˜A4 are generated using the threshold values a1˜a4that are set as described above.

Next, with reference to FIG. 5, a description will be given of a methodfor recognizing a plurality of particulates that continuously exist inthe radial direction of the analysis disc as shown in FIG. 4, asindividual particulates, from the generated memory arrays A1˜A4.

FIGS. 5( a)-5(d) show the states of the respective memory arrays in anarea including the particulates shown in FIG. 4. Particularly, FIG. 5(a) shows the memory array A1 corresponding to the threshold a1, FIG. 5(b) shows the memory array A2 corresponding to the threshold value a2,FIG. 5( c) shows the memory array A3 corresponding to the thresholdvalue a3, and FIG. 5( d) shows the memory array A4 corresponding to thethreshold value a4.

Scanning is carried out to search the array of FIG. 5( a) for a positionwhere the scanning point becomes 1 while sifting the scanning point oneby one in the row direction up to the right end, with the upper left endof FIG. 5( a) as a base point. When the scanning to the right end iscompleted, scanning is carried out with the left end of the next row asa base point, while shifting the scanning point one by one in the rowdirection up to the right end. This scanning is repeatedly carried out.

When it is detected that a 1 exists in the scanning point, a particulaterecognition process to be described later is carried out. After theparticulate recognition process is completed, scanning is continued withthe scanning point being shifted by one.

Hereinafter, the particulate recognition process will be described withreference to FIGS. 6( a)-6(d).

FIGS. 6( a)-6(d) are diagrams illustrating the states in the scanningwindow, for explaining the particulate size determination process. InFIGS. 6( a)-6(d), “1” indicates that there is at least one 1 in thecorresponding row in the scanning window, and “0” indicates that all ofthe scanning points in the corresponding row in the scanning window are0. That is, 1s and 0s shown in FIGS. 6( a)-6(d) are the results of ORcalculated in the row direction with respect to the respective rows inthe scanning window. The state of the scanning window 41 shown in FIGS.5( a)-5(b) is shown in FIG. 6( a). The state in the scanning window 41that will appear in the following description will be expressed asdescribed above.

FIG. 7 is a flowchart of the particulate recognition process accordingto the first embodiment.

Initially, in step S1, a scanning window 41, the range of which isextended as far as 1s continue in the row direction from the scanningpoint, is generated. This scanning window has a predetermined width inthe column direction. The predetermined width is a width in which all of1s generated with respect to one particulate remain in the scanningwindow, and it is previously obtained by actual measurement or the like.

Next, in step S2, the particulate size is obtained by performing aparticulate size determination process to be described later.

In step S3, with reference to the table shown in FIG. 3, the rows in thescanning window 41 in each memory array are successively cleared fromthe top, by the number of continuous 1s corresponding to the obtainedparticulate size (all of the data in one row are set to 0).

In step S4, it is judged whether, on the memory array A1, all of thedata in the scanning window 41 is 0 or not. When the result of judgementis true, i.e., when all of the data is 0, the particulate recognitionprocess is ended. On the other hand, when the result of the judgement isfalse, i.e., 1 still remains in any row, the operation goes back to stepS1 to continue the particulate recognition process.

FIG. 6( b) shows the state of the scanning window and the countingcondition at the point where the process reaches step S4 for the firsttime. In step S2, the particulate C is detected. In step S3, the rowswhere 1s exist are cleared over 5 rows in the memory array A1, 3 rows inthe memory array A2, and 1 row in the memory array A3. Since, at thispoint, 1s still remain in the scanning window 41, the process returns tostep S2 to continue the particulate recognition process.

FIG. 6( c) shows the state of the scanning window and the countingcondition at the point where the process reaches step S4 for the secondtime. In step S2, the particulate B is detected. In step S3, the rowswhere 1s exist are cleared over 3 rows in the memory array A1, and 1 rowin the memory array A2. Since, at this point, 1s still remain in thescanning window 41, the process returns to step S2 to continue theparticulate recognition process.

Thereafter, the processes from step S2 to step S4 are repeatedsimilarly. In step S2, the particulate A is detected in the third time,the fourth time, and the fifth time, and every time the particulate A isdetected, only one row where 1s exist on the memory array A1 is clearedin step S3. FIG. 6( d) shows the state of the scanning window and thecounting condition at the point of time when the process reaches step S4in the fifth time. At this point, all of the data in the scanning window41 is 0, and therefore, the particulate recognition process iscompleted.

Next, a description will be given of the particulate size determinationprocess to be carried out in step S2 described above.

FIG. 8 is a flowchart for explaining the particulate size determinationprocess according to the first embodiment.

In step S11, a variable n is initialized to 1. This variable n isemployed to express repetition of the process in the description of theflowchart.

In step S12, it is judged whether all of the data in the scanning window41 is 0 or not on the memory array An.

When the result of determination in step S12 is true, i.e., when all ofthe data in the window is 0, the process goes to step S13. In step S13,with reference to the table shown in FIG. 3, the particulate type isdetermined from the value of n. For example, when n=3, it is determinedas the particulate B in which the minimum threshold value at which no 1appears is the threshold value a3.

On the other hand, when the result of determination in step S12 isfalse, i.e., when 1 still remains in any row, the process goes to stepS14, and the value of n is incremented by one. Then, the process returnsto step S12 to continue.

By performing the above-mentioned scanning over the whole areas of thememory arrays, counting of particulates is carried out while determiningthe sizes of particulates.

As described above, according to the first embodiment, the S-shapedcurve detection circuit 9 constitutes plural memory arrays correspondingto different recognition conditions, and detects S-shaped curves usingthe different recognition conditions (threshold values). Then, theparticulate recognition circuit 10 analyzes a combination of appearancepatterns of 1s on the memory maps corresponding to the respectiverecognition conditions. Thereby, the number of particulates can becounted without wrongly recognizing plural particulates that arecontinuous in the radial direction of the disc.

Further, in this first embodiment, when the width of the S-shaped curveincreases in proportion to the size of the particulate, a similarparticulate size determination method can be applied by setting thethreshold values not in the amplitude direction but in the time-basedirection.

Furthermore, the PD detection signal according to the first embodimentmay be a convex signal as shown in FIG. 13, instead of the S-shapedcurve signal shown in FIG. 2( b). Also in this case, a similarparticulate size determination and counting can be carried out byconstituting the memory arrays with the threshold values being set likea1, a2, a3, and a4 as shown in FIG. 9.

Embodiment 2

Next, a particulate determination method according to a secondembodiment of the present invention will be described. A block diagramof a device to which the second embodiment is applied is identical tothat shown in FIG. 1 according to the first embodiment.

Hereinafter, a characteristic operation of the particulate determinationmethod according to the second embodiment will be described.

A description will be given of a threshold value b1 and a thresholdvalue b2 (b1<b2) corresponding to the amplitude of an S-shaped curve,and a memory array B1 and a memory array B2 which are generated usingthe respective threshold values.

FIG. 10 shows the number of 1s that appear continuously in the radialdirection on each memory array, when the particulates D, E, and F havingdifferent sizes exist.

When FIG. 10 is referred to for each particulate, the number of rows inwhich is appear continuously on the memory array B2 corresponding to thethreshold value b2 increases with an increase in the particulate size.For example, as for the smallest particulate D, the number ofoccurrences of 1s corresponding to the threshold value b2 is 0. As forthe largest particulate F, the number of occurrences of 1s 3.

The table shown in FIG. 10 will be used for particulate sizedetermination to be described later. Accordingly, this table should beprepared in advance, and the particulate type should be uniquelydetermined from the number of rows where 1s continuously appear withrespect to the threshold value b2, using this table. The respectivethreshold values are set to appropriate values so that all types ofparticulates can be uniquely determined.

The memory arrays B1 and B2 are generated using the threshold values b1and b2 which are set as described above. Next, a description will begiven of a method for recognizing the particulates which existcontinuously in the radial direction of the analysis disc as shown inFIG. 4, as individual particulates, from the generated memory arrays B1and B2, with reference to FIGS. 5( a)-5(d)

FIGS. 5( a)-5(d) show the states of the respective memory arrays in thearea including the particulates shown in FIG. 4. Particularly, FIG. 5(a) shows the memory array B1 corresponding to the threshold value b1,and FIG. 5( b) shows the memory array B2 corresponding to the thresholdvalue b2.

The memory array B1 is searched for a position where the scanning pointbecomes 1, with the upper left of FIG. 5( a) as a base point, whileshifting the scanning point one by one in the row direction up to theright end. When scanning up to the right end is completed, scanning iscarried out with the left end of the next row as a base point, whileshifting the scanning point one by one in the row direction up to theright end of the row. This scanning is repeatedly carried out.

When it is detected that 1 exists at a scanning point, a particulaterecognition process to be described later is carried out. After theparticulate recognition process, the scanning point is shifted by one tocontinue scanning.

Hereinafter, the particulate recognition process will be described withreference to FIGS. 11( a)-11(d). FIGS. 11( a)-11(d) show the states inthe scanning window 41, for explaining a particulate size determinationprocess. Since the method of expressing the states in the scanningwindow shown in FIGS. 11( a)-11(d) is identical to that described withrespect to FIGS. 6( a)-6(b) according to the first embodiment, repeateddescription is not necessary.

FIG. 12 is a flowchart of the particulate recognition process accordingto the second embodiment.

When the process is started, in step S21, a scanning window 41, therange of which is extended as far as 1s continue in the row directionfrom the scanning point, is generated. The scanning window 41 has apredetermined width in the column direction. The predetermined widthshould be previously obtained so that all of 1s generated for oneparticulate are contained in the scanning window 41.

Next, in step S22, on the memory array B2, the respective rows in thescanning window 41 are scanned from the top, and the number of rows inwhich 1s continue is counted from a row in which 1 is detected for thefirst time, and the size of the particulate is determined with referenceto the table shown in FIG. 10. For example, when the state in thescanning window 41 is as shown in FIG. 11( a), continuous 1s exist inthe three rows, i.e., from the third row to the fifth row, on the memoryarray B2, and therefore, it is determined as the particulate F from thetable shown in FIG. 10.

Next, in step S23, with reference to the table shown in FIG. 10, therows in the scanning window 41 of each memory array are clearedsuccessively from the top, by the number of continuous 1s correspondingto the size of the obtained particulate (all of the data in one row areset to 0).

In step S24, it is judged whether all of the data in the scanning window41 is 0 or not on the memory array B1. When the result of the judgmentis true, i.e., when all of the data is 0, the particulate recognitionprocess is ended. On the other hand, when the result of the judgment isfalse, i.e., when 1 still remains in any row, the process returns tostep S21, and the particulate recognition process 1s continued.

FIG. 11( b) shows the state in the scanning window 41 and the conditionof counting at the point of time when the process reaches step S24 forthe first time. The particulate F has been detected in step S22, andfive rows where 1s exist have been cleared in the memory array B1 whilethree rows where 1s exist have been cleared in the memory array B2, instep S23. At this time, since 1s still remain in the scanning window 41,the process returns to step S22 to continue the particulate recognitionprocess.

FIG. 11( c) shows the state in the scanning window 41 and the countingcondition at the point of time when the process reaches step S24 for thesecond time. The particulate E has been detected in step S22, and threerows where 1s exist have been cleared in the memory array B1 while onerow where 1 exists has been cleared in the memory array B2, in step S23.At this time, since 1s still remain in the scanning window 41, theprocess returns to step S22, and the particulate recognition process iscontinued.

Hereinafter, the processes of steps S22 to S24 are continued similarly.In step S22, the particulate D is detected in the third time, the fourthtime, and the fifth time, and every time the particulate D is detected,one row where 1 exists is cleared on the memory array B1 in the nextstep S23. FIG. 11( d) shows the state of the scanning window 41 and thecounting condition at the point of time when the process reaches stepS24 for the fifth time. At this time, all of the data in the scanningwindow 41 is 0, and therefore, the particulate recognition process isended.

By performing the above-mentioned scanning over the whole areas of thememory arrays, counting of particulates is carried out while determiningthe sizes of the particulates.

As described above, in the second embodiment, there are provided twopatterns of memory arrays, i.e., the memory array B1 corresponding tothe threshold value b1 and the memory array B2 corresponding to thethreshold value b2, and a combination of patterns of occurrences of 1 onthe respective memory arrays is analyzed, whereby the sizes ofparticulates can be recognized and the number of the particulates can becounted without wrongly recognizing the plural particulates thatcontinuously exist in the radial direction of the disc.

When the width of the S-shaped curve increases in proportion to theparticulate size, a similar particulate size determination method can beapplied by setting the threshold values not in the amplitude directionbut in the time axis direction.

Further, instead of the S-shaped curve signal shown in FIG. 2( b), aconvex signal as shown in FIG. 13 may be employed as a PD detectionsignal. Also in this case, similar particulate size determination andcounting can be carried out by constituting the memory arrays with thethreshold values being set like b1 and b2 shown in FIG. 13.

Embodiment 3

Next, a particulate determination method according to a third embodimentof the present invention will be described. FIG. 14( a) is a diagramillustrating a layout of particulates on an optical disc in theparticulate determination method according to the third embodiment ofthe present invention. FIG. 14( b) shows signal patterns correspondingto the particulates on the optical disc shown in FIG. 14( a). Further,FIG. 15 shows a memory array indicating a result of determination thatis performed on FIG. 14( b) according to a particulate recognitioncondition.

A block diagram of a device to which the particulate determinationmethod according to the third embodiment is applied is identical to theconstruction shown in FIG. 1 according to the first embodiment.

Hereinafter, characteristic processes in the particulate determinationmethod according to the third embodiment will be described.

It is assumed that, as shown in FIG. 14( a), a particulate G, aparticulate H, and a particulate I are placed over tracks 1 to 16 on theoptical disc. That is, the particulate G is placed on the tracks 2 and3, the particulate H is placed on the tracks 4 to 8, and the particulateI is placed on the tracks 9 to 15.

In this case, signal patterns generated along the respective tracksS-shaped patterns shown in FIG. 14( b) (hereinafter referred to asS-shaped curves). Each S-shaped curve appears within a range between twointersection points of each track and the outermost circumference ofeach particulate.

Next, a description will be given of a particulate recognition conditionin the case where only the particulate H is a target of measurement.FIG. 16 is a diagram illustrating that, among the tracks that intersectthe particulate H as a target of measurement, the center of two tracks(alternate long and short dashed line) passes the center o of theparticulate, wherein p indicates the track pitch of the optical disc,and r indicates the radius of the particulate H. At this time, thedistance d in FIG. 16 can be calculated out from formula (I).

$\begin{matrix}{d = \sqrt{r^{2} - \left( \frac{p}{2} \right)^{2}}} & (1)\end{matrix}$

Using 2d that is double the distance d, there is made a recognitioncondition that the size of the signal pattern in the time-base direction(the distance from a change start position to a change end position inthe track direction) is equal to or larger than 2d.

This recognition condition is applied to the S-shaped curves that appearfrom track 1 to track 16, and 1 is written on the memory array when theresult is true, while 0 is written on the memory array when the resultis false. Thus generated memory array is shown in FIG. 15.

Next, it is judged that, on the memory array shown in FIG. 15, a portionwhere plural 1s do not continuously exist in the vertical direction,i.e., a portion where 0s exist above and beneath 1, is a portion wherethe target particulate exists (judgment criteria A).

As for the particulate G that is not a target of measurement, no 1exists on the memory array. Further, as for the particulate I that isnot a target of measurement, plural 1s continuously exist in thevertical direction. Therefore, these particulates are removed accordingto the above-mentioned judgment criteria A.

That is, one particulate is detected from the memory array shown in FIG.15.

In this way, even when plural particulates having different sizes areadjacent to each other, only the target particulate H can be counted.

Next, the particulate recognition condition will be described. As shownin FIG. 16, when the center line between two tracks which pass theparticulate passes the center of the particulate, the lengths of theS-shaped curves in the two tracks in the time-base direction (thedistances between the change start positions to the change end positionsin the track direction) are equal to each other. In this case, when theabove-mentioned recognition condition is applied to the lengths of theS-shaped curves in the two tracks in the time-base direction (thedistances between the change start positions to the change end positionsin the track direction), the respective lengths satisfy formula (1)mentioned above, and therefore, two 1s are written on the memory array.

When the above-mentioned judgment criteria A is applied to this memoryarray, since plural 1s exist continuously in the vertical direction onthe memory array, these is are removed according to the judgmentcriteria, and are not counted as a particulate. So, when the lengths ofadjacent S-shaped curves in the time-base direction are equal to eachother, 1 is written on the memory array at only the positioncorresponding to the initially measured S-shaped curve, while a0, not a1is written on the memory array at the position corresponding to theS-shaped curve of the same length, which appears next. Thereby, theabove-mentioned judgment criteria A becomes applicable, and accuratecounting of particulates can be carried out.

As described above, according to the third embodiment, a particulaterecognition condition corresponding to the size of a particulate to bedetected is previously set, and 1 is written on the memory map only whenan S shape larger than the condition is detected. Therefore, even whenparticulates are adjacent to each other in the vertical direction,plural 1s are not continuously written in the vertical direction, andone particulate can be accurately recognized. Further, by counting onlythe case where only one 1 stands after window scanning, it is possibleto know the size and number of particulates to be detected by onetimescanning.

Embodiment 4

Next, a particulate determination method according to a fourthembodiment of the present invention will be described. FIG. 17 showsexamples of a layout range of a target of measurement on an optical discand layout ranges of reference targets to obtain reference patterns.FIG. 18 shows S-shaped curves obtained from the reference targets andthe measurement target.

Further, a block diagram of a device to which the particulatedetermination method according to the fourth embodiment is applied isidentical to the construction shown in FIG. 1 according to the firstembodiment.

Hereinafter, characteristic processes in the particulate determinationmethod according to the fourth embodiment will be described.

In FIG. 17, region A shows a layout range of a measurement target,region B shows a layout range of a reference target A having a size thatis equal to a minimum value of the size of the measurement target, andregion C shows a layout range of a reference target B having a size thatis equal to a maximum value of the size of the measurement target.

Before performing counting of the measurement target using such opticaldisc, S-shaped curves corresponding to the reference target A and thereference target B which are placed in the region B and the region C,respectively, are obtained. In FIG. 18, section “a” shows an S-shapedcurve corresponding to the reference target A, and section “b” shows anS-shaped curve corresponding to the reference target B. Then, themaximum levels of amplitudes of the obtained S-shaped curves of therespective reference targets are stored. That is, in FIG. 18, referenceline B shows the maximum level of the S-shaped curve corresponding tothe reference target A, and reference line A shows the maximum level ofthe S-shaped curve corresponding to the reference target B.

Likewise, the minimum levels of amplitudes of the S-shaped curves of therespective reference targets are stored. That is, in FIG. 18, referenceline C shows the minimum level of the S-shaped curve corresponding tothe reference target A, and reference line D shows the minimum level ofthe S-shaped curve corresponding to the reference target B. Next, anS-shaped curve of the measurement target placed in the region A isobtained using the same method as that described for the firstembodiment.

Then, it is judged whether the maximum level or minimum level of theS-shaped curve of the measurement target is within the range of themaximum levels obtained from the reference targets (section betweenreference lines A and B) or the range of the minimum levels obtainedfrom the reference targets (section between reference lines C and D),respectively. Only when the S-shaped curve obtained from the measurementtarget is within the range of the maximum levels obtained from thereference targets (section between reference lines A and B) or withinthe range of the minimum levels obtained from the reference targets(section between reference lines C and D), the process of recording datainto the memory, which is the same as those described for the first andsecond embodiments, is carried out using the S-shaped curve. Moreover,counting of particulates is carried out by the same method as that ofthe first or second embodiment.

Alternatively, it is judged whether the maximum level and the minimumlevel of the S-shaped curve of the measurement target are within therange of the maximum levels obtained from the reference targets (sectionbetween reference lines A and B) and the range of the minimum levelsobtained from the reference targets (section between reference lines Cand D), respectively. Only when the S-shaped curve obtained from themeasurement target is within the range of the maximum levels obtainedfrom the reference targets (section between reference lines A and B) andwithin the range of the minimum levels obtained from the referencetargets (section between reference lines C and D), the process ofrecording data into the memory, which is the same as those described forthe first and second embodiments, is carried out using the S-shapedcurve. Moreover, counting of particulates is carried out by the samemethod as that of the first or second embodiment.

As described above, the S-shaped curve of the measurement target isselected on the basis of the S-shaped curves of the reference targets,whereby the signals of the S-shaped curves obtained from the targetshaving the sizes other than that of the measurement target arepreviously removed. That is, when the S-shaped curves shown in thesections c, d, and e in FIG. 18 are obtained from the measurementtarget, the data recording process into the memory and the subsequentprocesses are carried out using only the S-shaped curve shown in thesection d. Thereby, accurate counting of particulates can be carried outusing only the S-shaped curve signal of the measurement target to becounted.

As described above, according to the fourth embodiment, utilizing thecharacteristic that the amplitude of a pattern is proportional to thesize (diameter) of a target, a maximum value and a minimum value of thesize (diameter) of a reference measurement target are previously set onan analysis disc, and distributions of maximum values and minimum valuesof signals which are obtained by measuring the size of the measurementtarget are obtained, and then it is determined whether the amplitude ofthe signal obtained when measuring the measurement target is within therange of the distribution of the maximum values or minimum values of theamplitude of the reference signal, whereby only the desired measurementtarget can be measured by onetime scanning without measuring the targetshaving sizes other than the size of the desired target.

Embodiment 5

FIG. 21( a) is a diagram illustrating particulate detection in aparticulate determination method according to a fifth embodiment of thepresent invention.

An analysis disc has light reflectivity and permeability, and it iscomposed of a base disc in which tracks 21 for guiding or data recordingare spirally carved, an upper cover having an injection port, and anadhesive layer for bonding the upper cover and the base disc, andforming a flow path.

A specimen for examination is injected into the analysis disc. Thespecimen passes through the flow path that is constituted by theadhesive layer, passes through the lower surface of the upper cover, andpasses through the upper surface of the base disc, and is subjected topretreatment such as centrifugal separation utilizing. Thus,particulates as measurement target components in the specimen reach anarea where measurement should be carried out.

In the measurement area, the particulates in the specimen exist on thesurface of the base disc due to a particulate adsorption factor(antibody or the like) that is applied onto the surface of the basedisc. The size of each particulate is larger than the width of the track201, and the particulate lies over plural tracks 201, as shown in FIG.21( a).

The analysis device has a two-part split PD for receiving a laser beam212 that has passed through the analysis disc, and a spot of the laseroutputted from an optical pickup is positioned in the center of the PDwhen there is no particulate on the analysis disc.

When a particulate crosses the laser, the position of the laser spot onthe PD is changed due to change in refraction of the laser beam, and theposition change of the spot is detected as an S-shaped signal byobtaining a difference between the signals from the two-part split PD.

At this time, as shown on the right side of FIG. 21( a), the size of theS-shaped curve 215 changes according to the size of the crossingparticulate 213. The larger the crossing particulate 213 is, the largerthe S-shaped curve 215 is.

FIG. 21( b) is a diagram illustrating the enlarged S-shaped curve 215 inthe particulate determination method according to the fifth embodiment.

When the S-shaped curve 215 is detected, is are not merely stored in thememory. When the size of the S-shaped curve is judged as being smalleston the basis of the size of ΔZ or ΔT shown in FIG. 21( b), “1000” isstored. Then, as the S-shaped curve becomes larger, “1100”, “1110” arestored, and “1111” is stored when the S-shaped curve is judged as beinglargest. In this way, a data array in which the size of the S-shapedcurve is divided in several stages is stored in the memory.

Hereinafter, a description will be given of the operation and functionwith respect to the particulate determination method according to thefifth embodiment of the present invention.

FIG. 22 is a diagram illustrating the particulate determination methodaccording to the fifth embodiment of the present invention.

Initially, when detecting a particulate having a size equivalent toseven tracks, as shown in FIG. 22( a), scanning is carried out using anoperation (detection) window 214 having a size of 7×X1 while shiftingthe window one by one in the X direction as the track direction, therebyto detect a portion where the first row of the detection window 214includes at least one 1.

When a 1 is detected, the detection window 214 is shifted one by one inthe track direction while monitoring the total number of 1s in each row,and finally, the detection window 214 is shifted to a position where thenumber of 1s in each row does not change even when the detection window214 is shifted in the track direction.

The state where the number of 1s in each row does not change even whenthe detection window 214 is shifted in the track direction indicatesthat all the is around the detection window are enclosed in thedetection window.

Next, at the position thus detected, it is judged whether or not each ofthe rows in the window having the size of 7×X1 includes one or more 1s.

When any of the rows does not include 1, the size of the particulate isjudged as being smaller than seven tracks, and this particulate is notcounted.

When each of the rows in the window having the size of 7 X1 includes oneor more is, increase or decrease of the number of 1s in each track ischecked. As shown in FIG. 22( b), when there is a portion where aconstriction as shown by a occurs, it is judged that there are pluralparticulates, and these particulates are counted separately.

Further, even though no constriction occurs, when there is a portionwhere the number of 1s constant without increase or decrease, it isjudged that a plurality of small particulates are arranged, and anothercounting should be carried out.

As for 1s in once-read positions, these is are deleted from the memory,and next window scanning is carried out. The number of particulateshaving sizes equal to or larger than seven tracks can be calculated bytaking a difference between the number of particulates obtained in thefirst scanning and that obtained in the second scanning.

When the scanning using the window having the size of 7×X1 is ended,scanning is carried out using a window having a size of 8×X1 whileshifting the window one by one in the X direction. Since is are deletedfrom the memory in the previous scanning, S-shape detection is againcarried out, and the detected S-shaped curve is stored in the memory.

Then, scanning is carried out using the window having the size of 8×X1while shifting the window one by one in the X direction, and thereafter,the same processing as that for the 7×X1 window is carried out.

Through a series of window operations described above, it is possible todetect the number of particulates having the sizes equivalent to orlarger than seven tracks, the number of particulates having the sizesequivalent to or larger than eight tracks, and the number ofparticulates each comprising a plurality of particulates. Moreover, thenumber of particulates having the size equivalent to seven tracks can beobtained by taking a difference.

While in this fifth embodiment the array of 1s is represented by fourlines of four stages “1000”˜“1111”, it may be represented by five lines(“10000”˜“11111”) or six lines (“100000”˜“111111”) to improveresolution, with the same effects as mentioned above.

As described above, in the particulate determination method according tothe fifth embodiment, the analysis disc into which a plurality ofparticulates 213 are injected is irradiated with the laser beam 212, thelaser beam 212 is detected with the PD, and the detected signal issubjected to data processing and stored in the memory to determineindependence of each particulate. This, method also includes a step ofstoring, into the memory, an array of binary data comprising 0s and 1s,which is determined on the basis of the presence or absence of aparticulate 213 and the size of the particulate 213, and a step ofdetermining the size of the particulate from the data arrays in thetrack direction and the radial direction of the analysis disc. When anS-shaped curve 215 is detected, the size of the S-shaped curve 215 isdivided into several stages, and information indicating the size of theS-shaped curve 215 is added to the data array on the memory. Therefore,it is possible to judge whether the particulate comprises a plurality ofparticulates or a single particulate, whereby a more accurate number ofparticulates can be obtained.

Embodiment 6

FIG. 23( a) is a diagram illustrating a particulate determination methodaccording to a sixth embodiment of the present invention, and FIG. 23(b) is a diagram illustrating a data array stored in a memory.

Since a method for detecting a particulate according to the sixthembodiment is identical to that of the first embodiment, repeateddescription is not necessary. This sixth embodiment is different fromthe first embodiment in that a data array indicating the presence orabsence of a particulate is “11”, and “110” is stored for windowdetection in the memory when an S-shaped curve is detected. The size ofthe S-shaped curve is divided into several stages, and further, “0001”is stored in the memory when it is judged that there is a particulate ofthe smallest S-shaped curve, while “1010” is stored in the memory whenit is judged that there is a particulate of the largest S-shaped curve.That is, the stages are assigned to arrays of 1s and 0s in whichcontinuous 1s do not exist.

For example, assuming that the array indicating the size of the S-shapedcurve comprises four digits, the size of the S-shaped curve can beclassified into eight stages 0, 1, 2, 4, 5, 8, 9, and 10.

As described above, since the array indicating the presence or absenceof a particulate is separated from the array indicating the size of theS-shaped curve, it becomes unnecessary in the position detection step tokeep a watch on the number of 1s in each row in the window. Therefore,the operation of the detection window is not complicated as comparedwith that of the first embodiment.

Further, in the case of four digits, the number of divided stages isseven and eight, which is not very much different from that of the fifthembodiment. However, in the case of five digits, the number of dividedstages is thirteen, which is five stages larger than that of the fifthembodiment, and therefore, it is advantageous for fine classification.

Hereinafter, a description will be given of the operation and functionof the particulate determination method according to the sixthembodiment constituted as described above.

Initially, when detecting a particulate having a size equivalent toseven tracks, scanning is carried out using a window 214 having a sizeof 7×X1 shown in FIG. 23( a), while shifting the window one by one inthe X direction as the track direction, and positions where all rowsinclude “11” as shown by the range β in FIG. 23( b) are counted.

When the compatibility condition is satisfied, the data are furtheranalyzed with respect to the range γ shown in FIG. 23( b). When there isa tendency that the size of the S-shaped curve decreases in somemidpoint in the rows in the window, it is judged that pluralparticulates exist, and these particulates are counted separately.

Once-read is are deleted from the memory to present one particulate frombeing counted twice, and S shape detection is again carried out beforeperforming scanning using another window, and detected S-shape curvesare stored in the memory.

Next, similar scanning is carried out using a window having a size of8×X1, and positions where all of the rows in the window include “11” arecounted, and further, positions where the size of the S-shaped curvetends to decrease at some midpoint in the rows in the window arecounted.

Through a series of window operations described above, it is possible todetect the number of particulates having the sizes equivalent to orlarger than seven tracks, the number of particulates having the sizesequivalent to or larger than eight tracks, and the number ofparticulates each comprising a plurality of particulates. Moreover, thenumber of particulates having the size equivalent to seven tracks can beobtained by taking a difference.

While in this sixth embodiment the data array indicating the size of theS-shaped curve is composed of four digits, it may be composed of five,six, . . . digits to improve resolution, with the same effects asdescribed above.

Further, even when the data array is composed of three digits, the sizeof the S-shaped curve can be classified into five stages. Even threedigits are adequate for determining whether there are a plurality ofparticulates or not.

As described above, in the particulate determination method according tothe sixth embodiment, the analysis disc into which a plurality ofparticulates 213 are injected is irradiated with the laser beam 212. Thelaser beam 212 is detected with the PD, and the detected signal issubjected to data processing and stored in the memory to determineindependence of each particulate. This method also includes a step ofwriting “0” on the memory in a position next to “11” that is a dataarray indicating the presence or absence of the particulate 3, and astep of writing, on the memory, the data array which is encoded on thebasis of the size of an S-shaped curve that is detected by the PD whenthe laser beam 2 crosses the particulate 3. When an S-shaped curve isdetected, the size of the S-shaped curve is divided into several stages.Information indicating the size of the S-shaped curve is added to thedata array on the memory, in addition to the information indicatingpresence/absence of the S-shaped curve. Therefore, the operation of thedetection window is simplified, and it is possible to detect whether theparticulate comprises a plurality of particulates or a singleparticulate, whereby more accurate number of particulates can beobtained.

Embodiment 7

FIG. 24( a) is a diagram illustrating a particulate determination methodaccording to a seventh embodiment of the present invention, and FIG. 24(b) is a diagram illustrating a data array stored in a memory. In FIG.24( b), the data array in the vertical direction indicates the radius ofa particulate.

In contrast to the fifth and sixth embodiments, this seventh embodimentis provided with a routine in which, when an S-shaped curve is detected,the size of the detected S-shaped curve is compared with the size of anS-shaped curve of the previous row. When the S-shaped curve of theprevious row is larger than the detected S-shaped curve, no array isstored on the memory. After detection of the S-shaped curve, thepresence or absence of a particulate is checked in the data array in theprevious row.

If there is no particulate in the previous row, “110” is stored forwindow detection in the memory. Next, the size of the S-shaped curve isclassified into several stages. Furthermore, the stages are assigned todata arrays of 1s and 0s in which continuous 1s do not exist, and a dataarray suited to the size of the S-shaped curve, which is detected fromamong the data arrays, is stored in the memory.

For example, assuming that the array indicating the size of the S-shapedcurve comprises four digits, the size of the S-shaped curve can beclassified into eight stages “0000”, “0001”, “0010”, “0100”, “0101”,“1000”, “1001”, and “1010”.

When an S-shaped curve is detected in the next row, the presence orabsence of a particulate in the previous row is checked.

Then, the data array indicating the size of the S-shaped curve of theprevious row is compared with the detected S-shaped curve. When thedetected S-shaped curve is larger than the S-shaped curve of theprevious row, “110” is stored for window detection in the memory. Next,the size of the S-shaped curve is classified into several stages.Furthermore, the stages are assigned to data arrays of 1s and 0s inwhich continuous 1s do not exist, and a data array suited to the size ofthe S-shaped curve, which is detected from among the data arrays, isstored in the memory.

If the detected S-shaped curve is smaller than the S-shaped curve of theprevious row, the data array indicating the presence or absence of theS-shaped curve and the size of the S-shaped curve is not stored on thememory.

As described above, in the particulate determination method according tothe seventh embodiment, when particulates having sizes equivalent to 6˜7tracks are to be detected, initially, detection of array in which “11”continues over three or more rows on the memory is carried out using awindow having a size of 3×X1.

After detecting particulates having sizes equivalent to 6 or more tracksusing the window of 3×X1, particulates having sizes equivalent to 8 ormore tracks are detected using a window having a size of 4×X1.

Then, the number of particulates having the sizes equivalent to 6 ormore tracks are subtracted from the number of particulates having thesizes equivalent to 8 or more tracks, whereby particulates having thesizes equivalent to 6˜7 tracks can be detected.

As described above, in the particulate determination method according tothe seventh embodiment, the analysis disc into which a plurality ofparticulates 213 are injected is irradiated with the laser beam 212, thelaser beam 212 is detected with the PD, and the detected signal issubjected to data processing and stored in the memory to determineindependence of each particulate. In this method, when the S-shapedcurve of the data array obtained during particulate detection is smallerthan that of the data array in the previous row, data is not stored onthe memory. Since no data array is stored on the memory when thedetected S-shaped curve is smaller than the S-shaped curve in theprevious row, even when there exist a plurality of particulates adjacentto each other, data are not connected in the vertical direction but areclearly distinguished, whereby more accurate number of particulates canbe obtained.

A particulate determination method according to the present inventionhas an effect that a plurality of particulates that are continuous inthe radial direction of a disc can be counted without false recognition.The method is also useful as, for example, a particulate counting methodemployed by an analysis device for counting the number of analysistargets. Further, even when a plurality of particulates are adjacent toeach other, the particulate determination method can accuratelydetermine each particulate as a target and therefore, it is useful formeasuring each target, and determining the number of targets.

1. A method for determining independence of a particulate as ameasurement target which is injected into an analysis disc, said methodincluding: storing, into a memory, an array of binary data comprising 0sand 1s, which is determined on a basis of a presence or absence of theparticulate and a size of the particulate; determining the size of theparticulate on the basis of the data array in a track direction and aradius direction of the analysis disc; and judging that there are pluralparticulates when it is detected that 1s continue in the data array inthe radius direction, and the number of 1s in the data array in thetrack direction decreases at least one of a plurality of rows of thedata array.
 2. A method for determining independence of a particulate asa measurement target in accordance with claim 1 wherein the data arrayin the track direction has a larger number of 1s when an S-shaped curve,which is a particulate detection signal and has a maximum value and aminimum value, is large, and has a smaller number of 1s when theS-shaped curve is small.
 3. The method for determining independence of aparticulate as a measurement target in accordance with claim 1, saidmethod further comprising writing a second data array based on a size ofan S-shaped curve which is a particulate detection signal and has amaximum value and a minimum value, on a memory, in a position next tothe data array indicating the presence or absence of the particulate. 4.A method for determining independence of a particulate as a measurementtarget in accordance with claim 3 wherein continuous 1s do not exist inthe second data array.
 5. A method for determining independence of aparticulate as a measurement target in accordance with claim 3 which isrealized by a particulate determination device comprising: an opticalpickup which is provided movably with respect to the analysis disc, andcomprises an optical system including a light source, an objective lens,an actuator for driving the objective lens in a rotation axis directionand a radius direction of the analysis disc, and a photodetector forconverting a reflected light from the analysis disc into electricity; aspindle motor as a rotation driving means for the analysis disc; a servocontrol circuit for performing focus servo control, tracking servocontrol, and spindle servo control on a basis of a signal outputted fromthe optical pickup; a photo detector (PD) for receiving a laser lightwhich has been emitted from the optical pickup and has passed throughthe analysis disc, and converting the light into electricity; anS-shaped curve detection circuit for detecting an S-shaped curve on abasis of an electric signal outputted from the PD; a memory for holdingan array of binary data which is processed on a basis of an outputsignal from the S-shaped curve detection circuit; and a particulaterecognition circuit for recognizing a particulate on a basis of datastored in the memory.
 6. A method for determining independence of aparticulate as a measurement target in accordance with claim 1 which isrealized by a particulate determination device comprising: an opticalpickup which is provided movably with respect to the analysis disc, andcomprises an optical system including a light source, an objective lens,an actuator for driving the objective lens in a rotation axis directionand a radius direction of the analysis disc, and a photodetector forconverting a reflected light from the analysis disc into electricity; aspindle motor as a rotation driving means for the analysis disc; a servocontrol circuit for performing focus servo control, tracking servocontrol, and spindle servo control on a basis of a signal outputted fromthe optical pickup; a photo detector (PD) for receiving a laser lightwhich has been emitted from the optical pickup and has passed throughthe analysis disc, and converting the light into electricity; anS-shaped curve detection circuit for detecting an S-shaped curve on abasis of an electric signal outputted from the PD; a memory for holdingan array of binary data which is processed on a basis of an outputsignal from the S-shaped curve detection circuit; and a particulaterecognition circuit for recognizing a particulate on a basis of datastored in the memory.
 7. A method for determining independence of aparticulate as a measurement target which is injected into an analysisdisc, said method including: storing, into a memory, an array of binarydata comprising 0s and 1s, which is determined on a basis of a presenceor absence of the particulate and a size of the particulate; determiningthe size of the particulate on the basis of the data array in a trackdirection and a radius direction of the analysis disc; and determiningthat there are plural particulates when 1s continue in the data array inthe radius direction, and the number of 1s in the data array in thetrack direction is the same in each of a plurality of rows of the dataarray.